Know the starting state
Record the original cell before treatment while preserving its identity.
Oncology response & treatment resistance
You know which cells survived.But who were they before treatment?
The answer to resistance may begin before treatment itself.
Most assays reveal an outcome. VitraCell advances state-to-fate research that connects a living cell's starting state, its response to treatment and its eventual fate—so researchers can investigate what made the survivors different.
Start with your cell model, treatment question, current assay and the decision you need to make.
The question behind the endpoint
BEFORE TREATMENTOriginal cell states
AFTER TREATMENTSurviving cells
The VitraCell approach
The survivors have a history. We want to connect it to their fate.
Traditional endpoints tell researchers what remained. VitraCell’s ΔSR framework examines whether following the same living cell through treatment adds information worth acting on.
Follow its response
Connect repeated observations to that same cell during a defined perturbation.
Link to its fate
Compare its history with an independent outcome and, where feasible, molecular context.
Where it matters
Real questions. Important cells.
We focus on cases where rare or heterogeneous cell behavior could change the next experiment.
Why did these cells survive treatment?
Investigate the original states and early responses associated with treatment persistence and resistance.
Explore oncology →Why do therapeutic cells behave differently?
Examine functional heterogeneity in CAR-T, TCR-T, TIL and NK cell research.
Explore cell therapy →What if the cells are hard to access?
Our viable rare-cell acquisition program begins with label-free recovery of circulating tumor cells from blood.
Explore rare-cell acquisition →Grounded in scientific research
Rare pretreatment states can shape what happens next.
Peer-reviewed work on treatment resistance informs VitraCell’s focus on the history of the original living cell.
Work with VitraCell
Start with the question. Define the evidence you need.
A focused research engagement begins with your model, intervention, existing assay and decision—not a one-size-fits-all instrument.
01Define
Frame the problem
Agree on the biological question, comparator and what a meaningful finding would look like.
02Study
Design the experiment
Build a bounded feasibility plan with appropriate measurements, controls and independent endpoints.
03Decide
Make the next move
Specify how the evidence would inform a follow-on experiment, refinement or stop decision.
Let’s investigate the missing information
What can’t your current assay explain?
Send us the cell model, treatment question and decision your team is trying to make.